Clobex/Vectical "effective" in managing psoriasis

French dermatology-focused drugmaker Galderma Laboratories says interim findings from a study of sequential treatment of plaque  psoriasis using Clobex (clobetasol propionate) spray 0.05% followed by  treatment with Vectical (calcitriol) ointment 3mcg/g showed positive  results.

While both products are indicated for the treatment of plaque  psoriasis, this study was conducted to confirm the safety and efficacy  of these products when used in a sequential regimen. In this study,  Clobex spray was used in the initial phase of the study to treat  moderate-to-severe plaque psoriasis. For subjects sufficiently clear  at the end of four weeks, Vectical ointment was applied twice-daily for  eight weeks. Success was evaluated at week-12 based on Overall Disease  Severity scores.

The interim results indicate that sequential treatment of plaque  psoriasis with Clobex spray followed by Vectical ointment is effective  in managing plaque psoriasis over a 12-week period. Additionally, the  interim results demonstrate that this sequential treatment regimen was  well tolerated, with the most commonly reported side effects including  mild-to-moderate itching, stinging and burning and telangectasias (small  dilated blood vessels near the surface of the skin).