Carvykti scores well in landmark CARTITUDE-4 study

3 July 2024

US healthcare giant Johnson & Johnson (NYSE: JNJ) yesterday released encouraging new data on the overall survival benefit of its Carvykti (ciltacabtagene autoleucel; cilta-cel).

The company presented positive results from a prespecified second interim analysis of the Phase III CARTITUDE-4 study evaluating Carvykti compared to standard therapies of pomalidomide, bortezomib and dexamethasone (PVd) or daratumumab, pomalidomide and dexamethasone (DPd) for the treatment of patients with relapsed or lenalidomide-refractory multiple myeloma after one prior line of therapy.

The interim analysis showed a statistically-significant and clinically meaningful improvement in overall survival (OS) for patients treated with Carvykti versus standard therapies. Safety data were consistent with the approved label.

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