Candel Thera Phase IIa CAN-2409 trial OS bests docetaxel

28 March 2025

US clinical stage biopharma Candel Therapeutics (Nasdaq: CADL) has announced final survival data from a Phase IIa clinical trial of CAN-2409 in patients with stage III/IV non-small cell lung cancer (NSCLC), inadequately responding to ICI treatment.

In a Phase IIa trial, CAN-2409 (also known as aglatimagene besadenovec) demonstrated median overall survival (OS) of 24.5 months in patients who had failed checkpoint inhibitor therapy — more than double the 9.8-11.8 months typically seen with docetaxel chemotherapy.

Candel said the trial's significance lies not just in raw survival numbers, but in the challenging patient cohort. Not withstanding the positive news, Candel’s shares fell 8% to $7.50.

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