BridgeBio’s Beyonttra approved in Japan

27 March 2025

Genetic diseases company BridgeBio Pharma (Nasdaq: BBIO) has announced that the Japanese Ministry of Health, Labor and Welfare has approved acoramidis, under the brand name Beyonttra, for the treatment of adults with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).

Alexion, a subsidiary of Anglo-Swedish pharma major AstraZeneca (LSE: AZN), will be responsible for all commercial activity in Japan for Beyonttra, a selective small molecule, orally administered, near-complete transthyretin (TTR) stabilizer. It has been approved in the USA under the brand name Attruby.

ATTR-CM is a progressive, fatal disease that presents as an infiltrative, restrictive cardiomyopathy resulting in heart failure.

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