Vernalis'V15886 fails to meet primary endpoint and seeks partnering on further development
UK biotech company Vernalis (LSE: VER) has announced a failure to meet the primary endpoint of its study on V158866 but intends to partner on any further clinical development.
The Phase II proof-of-concept study of V158866, a fatty acid amide hydrolase inhibitor, was investigating the therapy as a treatment for neuropathic pain as a result of spinal cord injury. The randomized, double-blind, placebo-controlled, two-period crossover study resulted in elevated endocannabinoid levels, but failed to meet its pain reduction primary endpoint on an intent-to-treat basis.
Vernalis does not plan to make any further investment in the program and will seek to partner on the therapy, as a Phase I study provided “encouraging” data in evaluating the safety, tolerability and pharmacokinetic effects of the compound.
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