Update on SNG001 in the ACTIV-2 Phase III trial for COVID-19 and variants

3 March 2022

Shares of Synairgen (LSE: SNG), the UK respiratory company developing SNG001, leapt more than 36% to 25.16 pence by late morning trading, after it announced an update on SNG001 in the ACTIV-2 Phase III trial for COVID-19 and on SNG001 activity against Delta and Omicron variants.

Due to the need to modify the study design in light of the emergence of the Omicron variant of SARS-CoV-2, the US National Institutes of Health (NIH) ACTIV-2 trial team has asked Synairgen to temporarily pause activities to prepare clinical supplies for ACTIV-2 Phase III until the timeline for the activation of this agent in the trial is clarified. Synairgen continues to await the Phase II data from the US NIH ACTIV-2 trial in home-based COVID-19 participants, expected by mid-year.

Synairgen also announced that in vitro studies conducted at Viroclinics-DDL in the Netherlands have shown that SNG001 has potent antiviral activity against SARS-CoV-2 Delta and Omicron variants at concentrations that are readily achievable following inhaled delivery of interferon beta.

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