Trial failure sets Oxurion on course for bankruptcy

21 November 2023

The fate of Belgian biopharma Oxurion (Euronext Brussels: OXUR) has been sealed.

Oxurion announced Monday that top-line data in its KALAHARI Phase II, Part B trial for diabetic macular edema (DME) failed to show that its novel PKal inhibitor, THR-149, improved vision as much as the comparator aflibercept, at month three, the study’s primary endpoint.

Aflibercept is the anti-VEGF therapy marketed by Regeneron (Nasdaq: REGN) and Bayer (BAYN: DE) under the brand name Eylea.

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