Tango terminates TNG348 program
Oncology-focused biotech company Tango Therapeutics (Nasdaq: TNGX) is to discontinue development of its TNG348 program due toxicity observed in the initial study cohorts.
The USP1 inhibitor was being studied in a Phase I/II trial evaluating safety, pharmacokinetics, pharmacodynamics and efficacy as a single agent and in combination with olaparib, a PARP inhibitor, in patients with BRCA1/2-mutant and other homologous recombination deficient (HRD)+ cancers.
"We will focus resources and capital on our existing portfolio, particularly our PRMT5 program"Grade 3/4 liver function abnormalities were observed in patients remaining on study longer than eight weeks, leading to the decision to terminate the program. No patient had yet received a combination of TNG348 and olaparib.
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