Takeda out-licenses global rights to PI3Kα-specific inhibitors
Japan’s largest drugmaker Takeda Pharmaceutical (TYO: 4502) has out-licensed global development, manufacturing and commercialization rights to serabelisib and two additional PI3Kα-specific inhibitors to privately held Petra Pharma.
The agreement grants New York-based Petra a license for all human therapeutic uses, except for a subset of undisclosed rare-disease indications, which Takeda had previously out-licensed.
Petra plans to initiate a Phase Ib/II study with serabelisib in late 2019 to advance pioneering research and insights in PI signaling pathways with a focus on PIK3CA-mutated solid tumors. The PI3K signaling pathway is a frequently mutated pathway in human cancer.
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