Sophiris stock slumps by 40% after trial death

26 June 2018

The death of a patient in a Phase IIb trial of topsalysin in localized prostate cancer caused shares in Sophiris Bio (Nasdaq: SPHS) to close more than 40% down on Monday.

This patient died on the same day as receiving their second administration of Sophiris’ pore-forming protein.

A statement from the US biotech said that the company was investigating the cause and, as a precaution, no additional patients would receive a second administration of topsalysin.

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