Shares in MacroGenics more than double after trial result

7 February 2019

Shares in MacroGenics (Nasdaq: MGNX) are trading up over 130% after the East Coast, USA-based biotech firm revealed positive Phase III data from the SOPHIA trial testing margetuximab against HER2-positive metastatic breast cancer.

The firm is evaluating the immune-enhancing monoclonal antibody, in combination with chemo, compared to Roche’s (ROG: SIX) Herceptin (trastuzumab), plus chemo.

MacroGenics says the trial met the primary endpoint of prolongation of progression-free survival (PFS), with a 24% risk reduction compared with the Herceptin group.

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