Setback for BMS' Opdivo and Yervoy in RCC

29 July 2022

US pharma major Bristol Myers Squibb (NYSE: BMY) has announced the failure of Part A of the Phase III CheckMate -914 trial, evaluating Opdivo (nivolumab) plus Yervoy (ipilimumab).

This study is testing the combination as an adjuvant treatment for patients with localized renal cell carcinoma (RCC) who have undergone full or partial removal of the kidney and who are at moderate or high risk of relapse.

Part A of the trial did not meet the primary endpoint of disease-free survival (DFS) as assessed by blinded independent central review.

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