Rubraca significantly improves PFS in 1st-line maintenance of ovarian cancer

31 March 2022

US biotech Clovis Oncology (Nasdaq: CLVS) saw its shares roar up 55% to $2.55 pre-market, as it unveiled positive top-line results from the monotherapy portion of the ATHENA (GOG 3020/ENGOT-ov45) trial (ATHENA-MONO) demonstrating Rubraca (rucaparib) as first-line maintenance treatment successfully achieved the primary endpoint of significantly improved investigator-assessed progression-free survival (PFS) in both populations in the primary efficacy analyses: HRD-positive and all patients randomized (ITT) compared to placebo.

Median PFS of 20.2 months for Rubraca versus 9.2 months for placebo in the ITT population

Benefit in PFS was also seen in the exploratory subgroups of patients with HRD-negative and BRCA mutant (BRCAm) tumors. The safety of Rubraca observed in the ATHENA-MONO study was consistent with both the US and European labels for the approved product.

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