Roche sells rights for cardio drug candidate inclacumab

24 August 2018

California, USA-based biotech Global Blood Therapeutics (Nasdaq: GBT) yesterday revealed that is picking up rights to a cardiovascular drug candidate for a mere $2 million upfront, but still saw its share fall 3.33% to $49.40.

GBT said it has entered into an exclusive worldwide licensing agreement with Swiss pharma giant Roche (ROG: SIX) for the development and commercialization of inclacumab, a novel fully human monoclonal antibody against P-selectin. GBT plans to develop inclacumab as a treatment for vaso-occlusive crises (VOC) in patients with sickle cell disease (SCD).

Under the terms of the accord, GBT will be responsible for all development, manufacturing, and commercialization of inclacumab worldwide. Roche will receive an upfront payment of $2.0 million from GBT and is eligible to receive up to around $125 million in development and commercialization milestone payments for the sickle cell disease indication. Additionally, Roche is eligible to receive tiered royalties based on net revenues for inclacumab.

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