Roche and Amgen collaborate on cancer immunotherapy study
US biotech major Amgen (Nasdaq: AMGN) has entered into a collaboration with Swiss pharma giant Roche (ROG: SIX) on a Phase Ib study to evaluate the safety and efficacy of talimogene laherparepvec (T-Vec), Amgen's investigational oncolytic immunotherapy, in combination with Roche's investigational anti-PDL1 therapy, atezolizumab (also known as MPDL3280A), in patients with triple-negative breast cancer and colorectal cancer with liver metastases.
The rationale for combining these two investigational agents is to activate an anti-tumor immune response with talimogene laherparepvec and to block inhibitory T cell checkpoints with atezolizumab, to potentially increase the anti-tumor activity relative to each agent alone.
Potential in several cancer types
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