Regeneron and Inovio pair up to trial GMB combination therapy
US biotech firms Regeneron Pharmaceuticals (Nasdaq: REGN) and Inovio Pharmaceutical (Nasdaq: INO) have joined forces for a Phase I/IIa immuno-oncology trial.
The study will be conducted by Inovio in patients with newly-diagnosed glioblastoma multiforme (GBM) and will evaluate Regeneron's PD-1 inhibitor, REGN2810, in combination with Inovio's INO-5401 T cell activating immunotherapy encoding multiple antigens and INO-9012, an immune activator encoding interleukin (IL)-12.
REGN2810 is also being developed under a multi-billion-dollar collaboration with French pharma major Sanofi (Euronext: SAN) and is currently in a Phase II advanced cutaneous squamous cell carcinoma trial.
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