Rare defeat for Keytruda, in gastric cancer

29 April 2019

The USA’s Merck & Co (NYSE: MRK) has suffered a setback for its star immuno-oncology therapy Keytruda (pembrolizumab), in gastric cancer.

The firm says an analysis of top-line results from the Phase III KEYNOTE-062 trial, which is evaluating the drug as both monotherapy and in combination with chemotherapy, missed key primary endpoints related to efficacy.

Merck is hoping to develop the therapy as a first-line treatment of advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma.

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