Puma Biotech presents mixed data on neratinib in glioblastoma
US Puma Biotechnology (Nasdaq: PBYI) announced that investigators presented results from the neratinib arm of the Phase II Individualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT Trial) at the 2021 Society for Neuro-Oncology Annual Meeting.
Although preliminary results did not achieve the primary endpoint, subgroup analyses demonstrated improved PFS in patients with EGFR activation and a non-significant trend toward improved overall survival in patients with EGFRVIII mutations. However, this is essentially another disappointmeneratinibnt in the search for a glioblastoma treatment.
Neratinib is already approved in the USA under the brand name Nerlynx for the treatment of various breast cancers.
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