Precision medicine for antibiotics? AZ-backed Entasis leads the way

6 February 2019

Anglo-Swedish pharma major AstraZeneca (LSE: AZN) spin-out Entasis Therapeutics (Nasdaq: ETTX) is applying precision medicine to antibiotics to address the growing global issue of antibiotic resistance. The biotech aims to restore health to people affected by serious pathogens – with exactly the right drug in exactly the right way.

With a differentiated, pathogen-targeted approach for patients with serious, drug resistant infections, Entasis is tackling some of the toughest serious infections caused by MDR-resistant Gram-negative bacteria. Entasis’ targeted-design platform has produced a pipeline of product candidates, including:

ETX2514SUL targeting A. baumannii infections associated with high mortality, rapidly-increasing rates of antibiotic resistance, growing significance as a hospital-acquired infection, and limited treatment options; partnered with Zai Lab. Preparing to initiate Phase III trial
Zoliflodacin targeting Neisseria gonorrhoeae (Uncomplicated gonorrhea), partnered with NIH, DNDi and GARDP. Phase II results published in NEJM; on track to initiate Phase III in first-half 2019
ETX0282CPDP targeting Enterobacteriaceae infections (Complicated UTIs); powered by CARB-X. Results from Phase I expected in the first half 1of 2019
Also using its platform to develop a novel class of antibiotics, non-β-lactam inhibitors of the penicillin-binding proteins (NBPs) (targeting Gram-negative infections).

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