Germany’s BioNTech (Nasdaq: BNTX) and partner Pfizer (NYSE: PFE) have just announced results from an initial laboratory study regarding the Omicron variant. The data demonstrates that three doses of the Pfizer-BioNTech COVID-19 vaccine, trade named Comirnaty, neutralize the Omicron variant (B.1.1.529 lineage), while two doses show significantly reduced neutralization titers (by 25-fold).
As 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, two doses may still induce protection against severe disease, the companies noted.
The companies will continue to collect more laboratory data and evaluate real-world effectiveness to assess and confirm protection against Omicron and continue to advance the development of a variant-specific vaccine for Omicron. Should an adaption of the vaccine be necessary to further increase the level and duration, the companies expect to have it available by March.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze