Positive results for Valneva's inactivated COVID-19 vaccine vs Omicron variant
Though lacking in detail, results from an initial laboratory study demonstrating that serum antibodies induced by three doses of French vaccine maker Valneva’s (Nasdaq: VALN) inactivated COVID-19 vaccine candidate, VLA2001, neutralize the Omicron variant, still managed to send the firm’s stock rocketing 45%.
Sera from 30 participants in the Phase I/II trial VLA2001-201 were used in a pseudovirus assay to analyze neutralization of the ancestral SARS-CoV-2 virus as well as the Delta and Omicron variants.
All 30 samples (100%) presented neutralizing antibodies against the ancestral virus and Delta variant, and 26 samples (87%) presented neutralizing antibodies against the Omicron variant. The mean fold reduction of neutralization relative to the ancestral virus was 2.7-fold for Delta and 16.7-fold for Omicron.
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