Phase III win for out-licensed Regeneron asset

30 June 2020

Efforts to broaden the use of interleukin ((IL)-1 blocker rilonacept have been met with Phase III success, lifting shares in Bermuda-incorporated Californian firm Kiniksa Pharmaceuticals (Nasdaq: KNSA) by neary 20% including after-hours trading.

Discovered and developed by Regeneron Pharmaceuticals (Nasdaq: REGN), the therapy has been sold for some years as Arcalyst, for the treatment of cryopyrin-associated autoinflammatory syndrome (CAPS).

In 2017, Kiniksa gained the rights to develop the therapy against diseases believed to be mediated by both IL-1α and IL-1β, including recurrent pericarditis.

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