Phase III trials on tenofovir alafenamide meet primary endpoints
Two Phase III trials on tenofovir alafenamide (TAF) for hepatitis B virus (HBV), being conducted by US biotech major Gilead Sciences (Nasdaq: GILD), have met their primary endpoints, it has been reported.
Studies 108 and 110 showed that TAF was non-inferior to Gilead’s Viread (tenofovir disoproxil) based on the percentage of patients with HBV DNA levels below 29IU/mL at 48 weeks of therapy.
The once-daily drug showed improved renal and bone safety, according to the company.
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