Phase III Keytruda trial misses endpoint in head and neck cancer
People with head and neck cancer did not receive a statistically-significant benefit from treatment with Merck & Co’s (NYSE: MRK) Keytruda (pembrolizumab) in the KEYNOTE-412 trial.
The late-stage study has been evaluating the checkpoint blocker with concurrent chemoradiation therapy, followed by Keytruda as maintenance therapy, for people with unresected locally advanced cancer.
While there was an improvement in event-free survival (EFS) in the final analysis, it was not enough for the study to meet the primary endpoint.
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