Phase III Imfinzi combo trial misses endpoints

24 April 2018

AstraZeneca (LSE: AZN) has again reported disappointing clinical results for its now approved lung cancer drug Imfinzi (durvalumab) when it is combined with tremelimumab, sending the Anglo-Swedish pharma major’s shares 1% lower this morning.

The company announced high-level results from the Phase III ARCTIC trial in patients with locally-advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least two prior treatments.

The result of the study are not a huge surprise, since evidence has been building that there may be little value in using a so-called CTLA-4 drug like tremelimumab on top of a PD-L1 such as Imfinzi.

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