Phase III data boost Torii's hope of winning first AD indication for JAK inhibitor

16 January 2018

Top-line results from a Phase III study in Japan have been published, revealing that the experimental JAK inhibitor JTE-052 met its primary endpoint of superiority over placebo in the treatment of atopic dermatitis (AD).

The candidate is under development by Tokyo-based Torii Pharmaceutical (TSE:4551) in partnership with Japan Tobacco (TSE: 2914), a tobacco firm with a small pharmaceuticals division.

While JAK inhibitors have been approved for certain rheumatic conditions, none have yet secured approval in dermatology. One product in veterinary medicine - Apoquel (oclacitinib) for canine AD - has been approved.

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