Phase II study of varlitinib fails endpoint in gastric cancer
A global placebo-controlled, double-blind Phase II clinical study of varlitinibas a first-line therapy in HER1/HER2 co-expressing advanced or metastatic gastric cancer patients, comparing varlitinib plus mFOLFOX6 to placebo plus mFOLFOX6did not meet the primary endpoint of significant reductions in tumor size after 12 weeks of treatment.
Clinical-stage oncology-focused, Singapore-based biotech Aslan Pharmaceuticals (Nasdaq: ASLN) acquired full commercial rights for varlitinib from USA-based Array BioPharma a year ago in a potential $129 million deal.
News of the disappointing study results sent Aslan’s shares 9.3% lower to $3.22 by close of New York trading on Monday.
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