Pfizer walks away, sends Sangamo shares falling again

2 January 2025

Pfizer (NYSE: PFE) has unexpectedly decided to end its collaboration with Sangamo Therapeutics (Nasdaq: SGMO) on giroctocogene fitelparvovec (giro-vec).

The end of the collab, which focused on an investigational gene therapy for hemophilia A, comes despite strong Phase III data and planned regulatory submissions.

The decision comes shortly after the AFFINE trial, a Phase III study, demonstrated a significant reduction in mean total annualized bleeding rate compared to standard Factor VIII prophylaxis treatment.

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