Pfizer returns vupanorsen rights to Ionis

31 January 2022

Shares of Ionis Pharmaceuticals (Nasdaq: IONS) dropped a relatively modest 5.3% to $30.00 in early trading, as its partner US pharma giant Pfizer (NYSE: PFE) said it was pulling out of their collaboration on the ANGPTL3 protein-targeting drug vupanorsen.

The companies today announced the discontinuation of the Pfizer-led clinical development program for vupanorsen (PF-07285557), an investigational antisense therapy that was being evaluated for potential indications in cardiovascular (CV) risk reduction and severe hypertriglyceridemia (SHTG).

Pfizer made this decision after a thorough review of data from the global Phase IIb, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, eight-arm parallel-group study of vupanorsen in statin-treated participants with dyslipidemia - also known as TaRgeting ANGPTL3 with an aNtiSense oLigonucleotide in AdulTs with dyslipidEmia (TRANSLATE-TIMI 70).

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