Orbit Discovery and Endevica Bio in cachexia therapeutics deal

1 February 2023

UK-based Orbit Discovery, which calls itself a ‘leader in the discovery of therapeutic peptide hits’, has announced a collaboration.

Orbit has entered into a multi-target research agreement with Endevica Bio, a privately-held US company creating therapeutics for cachexia caused by cancer and other chronic conditions.

The collaboration aims to accelerate Endevica’s development of advanced G-protein coupled receptor (GPCR)-targeting therapeutics on receptor sets both novel and complimentary to its lead compound, which has been shown to be safe and well-tolerated in Phase I trials. Endevica’s tech platform allows for the modification of peptides to modulate activity of GPCRs behind the blood-brain barrier.

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