Novartis' Scemblix approved by the EC for CML

30 August 2022

The European Commission (EC) has approved Scemblix (asciminib) for the treatment of adult patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP), previously treated with two or more tyrosine kinase inhibitors (TKIs).

Swiss pharma giant Novartis’ (NOVN: VX) Scemblix is the first CML treatment in Europe that works by specifically targeting the ABL myristoyl pocket (also known as a STAMP inhibitor in scientific literature), offering a reimagined treatment approach for patients who experience intolerance and/or resistance to currently available TKI therapies.

Scemblix has received approval in several countries, including the USA, Japan, Switzerland, and the UK, for adult patients with Ph+ CML-CP with resistance or intolerance to at least two or more previous therapies.

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