Novartis' canakinumab fails again

15 August 2022

Swiss pharma giant Novartis (NOVN: VX) has announced that the Phase III CANOPY-A study evaluating adjuvant treatment with canakinumab, an inhibitor of interleukin-1beta did not meet its primary endpoint of disease-free survival versus placebo.

The multicenter, randomized, double blind study evaluated the efficacy and safety of the drug as adjuvant treatment in patients with NSCLC stages II-IIIA and IIIB whose margins are free of cancer following surgery.

The disapointing results are not a first for Novartis, as the company has already made several unsuccessful attempts to expand canakinumab to other therapeutic settings.

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