Novartis halts iscalimab study in kidney transplant
Swiss pharma giant Novartis (NOVN: VX) has announced that, following an interim analysis of data from the CIRRUS-1 study, a decision has been taken to discontinue the Phase IIb trial.
The analysis indicated that treatment based on iscalimab (CFZ533) is less efficacious compared to tacrolimus-based treatment in the prevention of organ rejection in patients receiving a kidney transplant.
Both iscalimab and the standard-of-care treatment were used in combination with other immunosuppressive therapies, namely induction therapy, mycophenolate and corticosteroids.
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