The big-selling immuno-oncology drug Opdivo (nivolumab) will not be funded for treating locally advanced unresectable or metastatic urothelial carcinoma in the UK, where this condition is the seventh most common cancer.
Opdivo, from US pharma major Bristol-Myers Squibb (NYSE: BMY), has been recommended previously by the National Institute for Health and Care Excellence (NICE), the cost-effectiveness watchdog for England and Wales, in other cancer indications.
But the NICE’s stance in the most common form of bladder cancer is different. On Wednesday it issued guidance not recommending the drug in this setting in adults who have had platinum-containing therapy.
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