NICE reverses Alunbrig stance
The National Institute for Health and Care Excellence (NICE) has recommended Alunbrig (brigatinib) being provided on the National Health Service (NHS) in England for anaplastic lymphoma kinase (ALK)-positive advanced non-small-cell lung cancer (NSCLC) in adults who have already had Xalkori (crizotinib).
This guidance within a final appraisal document (FAD) follows negotiations involving the drug company Takeda (TYO: 4502), the NICE, NHS England, and the clinical and patient community to reverse the draft negative recommendation published in October 2018.
The first ALK inhibitor to be available, Pfizer’s (NYSE: PFE) Xalkori (crizotinib), has had a significant impact on the outcome of ALK-positive NSCLC patients over recent years, with the majority of patients that received it in clinical trials progressing within a year.
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