NewLink accepts need to reconsider indoximod combo trial

17 April 2018

For a second day this month, US biotech NewLink Genetics (Nasdaq: NLNK) has taken a serious hit in the stock market.

Earlier in the month, the Iowa-based group suffered a 43% hit in a single day after announcing a review of its clinical programs prompted by rival company Incyte’s (Nasdaq: INCY) failure in the ECHO-301 melanoma trial.

Incyte had been evaluating the IDO pathway inhibitor epacadostat in combination with Merck & Co’s (NYSE: MRK) Keytruda (pembrolizumab), and the failure undermined confidence in IDO therapies, which NewLink is also developing.

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