Japan’s largest drugmaker Takeda Pharmaceutical (TYO: 4503) has announced findings from two new interim analyses of data from the Phase III HELP (Hereditary Angioedema Long-term Prophylaxis) Study Open-label Extension (OLE) at the 2020 European Academy of Allergy and Clinical Immunology (EAACI) Digital Congress.
The analyses suggest that Takhzyro (lanadelumab) is well-tolerated and can prevent hereditary angioedema (HAE) attacks over an extended treatment period, with sustained and consistent reduction in monthly attack rate across a range of different patient subgroups.
Takhzyro, which has been approved in the USA, the European Union, Canada, Australia and elsewhere, was developed by Shire, which Takeda acquired in a $62 billion deal. The drug generated sales 68 billion yen (~$630 million) for the latest financial year ended March 2020, up 602% from 10 billion yen the previous year.
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