New analyses of tramiprosate data presented at CTAD
Closely-held US biotech firm Alzheon has presented new analyses of previous Phase III data for tramiprosate, an investigational amyloid anti-aggregation agent and the active molecule of prodrug ALZ-801, in an oral presentation at the 9th annual Clinical Trials on Alzheimer’s Disease (CTAD) conference in San Diego.
- The new results strengthen Alzheon's precision medicine approach which identifies distinct biological phenotypes in Alzheimer’s disease (AD) patients.
- These phenotypes were described in the recently-published analyses of the tramiprosate Phase III data, showing that AD patients who carry two e4 alleles of apolipoprotein E gene (APOE4/4 homozygotes) respond with the largest clinical benefits.
- The results show tramiprosate’s largest efficacy signals on cognition and function in APOE4/4 homozygous patients with mild AD, defined as MMSE of 22 and higher.
Alzheon also presented a poster on the Phase I clinical studies and bridging data for ALZ-801, an optimized prodrug of tramiprosate, that support the pivotal clinical program planned to begin in 2017, which will evaluate ALZ-801 as a potential disease-modifying treatment for APOE4/4 homozygous patients at the mild stage of Alzheimer’s disease.
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