Moderna shows its Omicron booster bests Spikevax

19 October 2022

US messenger RNA (mRNA) Moderna (Nasdaq: MRNA) today announced new clinical data on its bivalent Omicron-containing booster, mRNA-1273.214, demonstrating its superiority of the biotech’s original COVID-19 vaccine Spikevax.

Moderna notes that 90 days after administration as a fourth booster dose in previously vaccinated and boosted participants, a 50µg booster dose of mRNA-1273.214 elicited a superior neutralizing antibody response against Omicron BA.1 when compared to a 50µg booster dose of mRNA-1273 (which is marketed under the trade name Spikevax, in all participants regardless of prior infection. Superior performance against Omicron BA.1 was also durable, with higher antibody titers sustained through three months. Spikevax recorded sales of over $7 billion last year.

Markets, however, were unimpressed, as Moderna’s shares were down 6.9% at $124.84 by early afternoon.

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