Moderna's cancer vaccine powers on with AACR data

17 April 2023

US biotech Moderna (Nasdaq: MRNA) continues to add to the optimism over mRNA-4157 (V940), its investigational cancer vaccine being developed alongside Merck & Co (NYSE: MRK).

The mRNA specialist has announced the first presentation of detailed results from the Phase IIb KEYNOTE-942/mRNA-4157-P201 trial evaluating the vaccine alongside Keytruda (pembrolizumab), Merck's anti-PD-1 therapy, in patients with resected high-risk melanoma (stage III/IV).

In the overall intention-to-treat population, adjuvant treatment with mRNA-4157 (V940) in combination with Keytruda demonstrated a statistically-significant and clinically-meaningful improvement in recurrence-free survival (RFS), and reduced the risk of recurrence or death by 44% compared with Keytruda alone.

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