Mersana mauled after deaths prompt clinical hold

16 June 2023

USA-based Mersana Therapeutics (Nasdaq: MRSN) has announced that the US Food and Drug Administration (FDA) has issued a partial clinical hold pausing patient enrollment in UP-NEXT and UPGRADE-A, the trials of UpRi in platinum-sensitive ovarian cancer.

Shares in the antibody-drug conjugate specialist closed 59% lower on Thursday following the announcement of the news.

UP-NEXT is a Phase III study while UPGRADE-A is a Phase I study.

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