Me-toos close in on Bioverativ's next-gen hemophilia portfolio

29 September 2017
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Before Bioverativ (Nasdaq: BIVV) found a way to extend the half life of recombinant factor therapies, hemophilia patients required a transfusion as often as every other day, resulting in higher bleed frequency and associated morbidity.

The new approach, in which a fragment of the immunoglobulin protein Fc is fused to clotting factor, is significantly more stable once injected into the body. This makes the treatment last for days or even weeks.

Alprolix (coagulation factor recombinant) for hemophilia B and Eloctate (antihemophilic factor recombinant) for hemophilia A gained US FDA approval in 2014. The products are commercialized in Europe by Swedish Orphan Biovitrum (STO: SOBI).

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