Markets maul Aerpio on trial failure

19 March 2019
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US biopharma Aerpio Pharmaceuticals (Nasdaq:ARPO) lost 71% of its market value on Monday based on top-line results from the company’s TIME-2b study.

The Phase IIb trial was designed to assess the efficacy and safety of Aerpio’s lead candidate, AKB-9778, for patients with moderate to severe non-proliferative diabetic retinopathy (NPDR).

Administration of AKB-9778 twice daily did not meet the study’s primary endpoint of the percentage of patients with an improvement of two or more steps in the study eye diabetic retinopathy severity score (DRSS) compared to placebo.

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