Marengo strikes second deal with Ipsen to advance T cell engagers

7 June 2024

June 7, 2024

USA-based immuno-oncology firm Marengo Therapeutics today announced a second strategic partnership with French drugmaker Ipsen (Euronext: IPN) to advance precision T cell engagers (TCEs) from Marengo’s next-generation TriSTAR platform.

Traditional TCEs targeting ‘cold’ tumors have limited efficacy due to poor T cell quality and exhaustion. Marengo’s proprietary first-in-class TriSTAR TCEs have the potential to overcome these limitations, redirecting a new and expanded pool of highly activated memory Vβ T cells to the tumor. The teams will focus on exploring potential in ‘cold’ tumors which typically fail to trigger a strong immune response when treated with TCEs.

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