MacroGenics and Takeda link up to develop DART for autoimmune disorders

27 May 2014

Privately held US biotech firm MacroGenics and Japan’s largest drugmaker Takeda Pharmaceutical (TYO: 4502) have entered into an option agreement for the development and commercialization of MGD010, which could earn the former more than half a billion dollars.

This product candidate incorporates MacroGenics' proprietary platform for dual-affinity re-targeting (DART) to simultaneously engage CD32B and CD79B, which are two B-cell surface proteins. MGD010 is currently in preclinical development for the treatment of autoimmune diseases.

Under the terms of the deal, MacroGenics will get an upfront of $15 million and Takeda receives an option to obtain an exclusive worldwide license for MGD010 following the completion of a pre-defined Phase Ia study. MacroGenics will lead all product development activities until that time. If Takeda exercises its option, it will assume responsibility for future development and pay MacroGenics an option exercise fee which, when combined with the upfront payment and an early development milestone, will total $33 million.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK

Companies featured in this story

More ones to watch >


Today's issue

Company Spotlight





More Features in Biotechnology