Lokon and Roche to study I-O combination

3 July 2019

Swedish biotech Lokon Pharma, currently developing LOAd703, a potent double-armed (TMZ-CD40L/4-1BBL) oncolytic adenovirus for solid tumors, has announced a collaboration with Swiss pharma giant, Roche (ROG: SIX).

The combination of LOAd703 and Roche’s anti-PD-L1 checkpoint antibody, Tecentriq (atezolizumab), will be tested in pancreatic cancer and melanoma.

An ongoing Phase I/IIa study (LOKON001) at Baylor College of Medicine, Houston, for patients with advanced pancreatic cancer, will be expanded to include Tecentriq.

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