Lilly's Taltz bests Humira in psoriatic arthritis

18 December 2018

US pharma major Eli Lilly (NYSE: LLY) saw its shares close down 3.19% at $108.36 yesterday, despite releasing positive clinical trial results with its interleukin (IL)-17 inhibitor compared to the world’s best selling prescription drug Humira (adalimumab).

Lilly announced that its Taltz (ixekizumab) met the primary and all major secondary endpoints in the Phase IIIb/IV SPIRIT-H2H study, which evaluated the efficacy and safety of Taltz versus Humira in patients with active psoriatic arthritis (PsA) who are biologic disease-modifying anti-rheumatic drug (DMARD)-naive.

The SPIRIT-H2H trial is the first completed large head-to-head (H2H) superiority study in active PsA. This open-label, randomized, controlled trial is the first and only H2H study that utilizes on-label dosing for both Taltz and Humira and includes concomitant conventional DMARDs.

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