Lilly's mirikizumab meets Phase III goals Crohn's disease

13 October 2023

US pharma major Eli Lilly (NYSE: LLY) said its investigational interleukin-23p19 antagonist, mirikizumab, met the co-primary and all major secondary endpoints compared to placebo in VIVID-1, a Phase III study.

The clinical trial was evaluating the safety and efficacy of mirikizumab for the treatment of adults with moderately to severely active Crohn's disease. The double-blind, treat-through trial included mirikizumab, placebo and active control (ustekinumab) arms.

Crohn's disease is a form of inflammatory bowel disease (IBD) that can cause systemic inflammation manifested as abdominal pain, diarrhea, fever and weight loss. It can lead to intestinal obstruction, fibrosis and other complications.

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