Lilly's Lartruvo fails in Phase III soft tissue sarcoma study

21 January 2019

US pharma major Eli Lilly (NYSE: LLY) saw its shares close down 2.16% at $115.59 on Friday, after it released disappointing results with its cancer treatment Lartruvo (olaratumab) and said it was suspending promotion of the drug.

Lilly reported that the results of ANNOUNCE, the Phase III study of Lartruvo, in combination with doxorubicin in patients with advanced or metastatic soft tissue sarcoma (STS), did not confirm the clinical benefit of Lartruvo in combination with doxorubicin as compared to doxorubicin, a standard of care treatment.

Specifically, the study did not meet the primary endpoints of overall survival (OS) in the full study population or in the leiomyosarcoma (LMS) sub-population; there was no difference in survival between the study arms for either population. Lartruvo was well tolerated; there were no new safety signals identified and the safety profile was comparable between treatment arms. Lilly plans to present the ANNOUNCE data at an upcoming medical conference and will publish the results in a medical journal.

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