Ligand grants rights to use Captisol in the formulation of AMG 330

18 July 2017

US drugmaker Ligand Pharmaceuticals (Nasdaq: LGND) has entered into a commercial license and supply agreement with biotech giant Amgen (Nasdaq: AMGN), granting rights to use Ligand’s Captisol technology in the formulation of AMG 330.

Captisol is a patent protected, chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. AMG 330 is an anti-CD33 x anti-CD3 (BiTE) bispecific antibody construct. It is being investigated as a treatment for acute myeloid leukemia by Amgen.

This license agreement replaces the prior research agreement which allowed Amgen to evaluate AMG 330 with Captisol in preclinical and early clinical studies. Under this new commercial license agreement, Amgen receives exclusive worldwide rights to combine Captisol with AMG 330 for use in humans for a wide variety of therapeutic indications. In addition to an upfront payment, Ligand is entitled to potential milestone payments, royalties and revenue from future sales of AMG 330 formulated using Captisol. Further financial terms were not disclosed.

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